CAG-Expansion Haplotype Analysis in a Population with a Low Prevalence of Huntington's Disease

@inproceedings{Pulkes2014CAGExpansionHA,
  title={CAG-Expansion Haplotype Analysis in a Population with a Low Prevalence of Huntington's Disease},
  author={Teeratorn Pulkes and Chutima Papsing and Sukanya Wattanapokayakit and Surakameth Mahasirimongkol},
  booktitle={Journal of clinical neurology},
  year={2014}
}
BACKGROUND AND PURPOSE The prevalence of Huntington's disease (HD) among East Asians is less than one-tenth of that among Caucasians. Such a low prevalence may be attributable to a lack of carriers of specific predisposing haplogroups associated with the high instability of the Huntingtin gene (HTT). The aim of this study was to evaluate the association between specific HTT haplogroups and the occurrence of HD in a Thai population. METHODS CAG-repeat sizes and HTT haplotypes were analyzed in… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

surement of mutational flow implies both a high newmutation rate for Huntington disease and substantial underascertainment of late - onset cases

  • MA Ramos-Arroyo, S Moreno, A Valiente
  • Am J Hum Genet
  • 2001

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