CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory.

@article{Song2007CAF1IE,
  title={CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory.},
  author={Yanjun Song and Feng He and Gengqiang Xie and Xiaoyan Guo and Yanjuan Xu and Yixu Chen and Xuehong Liang and Igor Stagljar and Dieter Egli and Jun Ma and Renjie Jiao},
  journal={Developmental biology},
  year={2007},
  volume={311 1},
  pages={
          213-22
        }
}
DNA synthesis during S-phase and upon DNA repair is accompanied by chromatin assembly. The chromatin assembly factor CAF-1 has been biochemically well-characterized to deposit histones onto newly synthesized DNA. To gain insights into the in vivo functions of CAF-1 in Drosophila, we generated null mutants of the largest subunit of dCAF-1, dCAF-1-p180. We show that, unlike CAF-1 mutant yeast, dCAF-1-p180 mutant flies are hemizygous lethal. Removal of maternal dCAF-1-p180 activity by germline… CONTINUE READING
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