CAF-1 Is Essential for Heterochromatin Organization in Pluripotent Embryonic Cells

@article{Houlard2005CAF1IE,
  title={CAF-1 Is Essential for Heterochromatin Organization in Pluripotent Embryonic Cells},
  author={Martin Houlard and Soizik Berlivet and Aline V. Probst and Jean-Pierre Quivy and P Mauridhy Hery and Genevi{\`e}ve Almouzni and Matthieu G{\'e}rard},
  journal={PLoS Genetics},
  year={2005},
  volume={2},
  pages={122 - 128}
}
During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1 (CAF-1) during pre-implantation development, we generated a mouse line carrying a targeted mutation in the gene encoding its large subunit, p150CAF-1. Loss of p150CAF-1 in homozygous mutants leads to developmental arrest at the 16-cell stage… CONTINUE READING

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