CACNA1S expression in mouse retina: Novel isoforms and antibody cross-reactivity with GPR179.

@article{Hasan2016CACNA1SEI,
  title={CACNA1S expression in mouse retina: Novel isoforms and antibody cross-reactivity with GPR179.},
  author={Nazarul Hasan and Thomas A. Ray and Ronald G Gregg},
  journal={Visual neuroscience},
  year={2016},
  volume={33},
  pages={
          E009
        }
}
Cacna1s encodes the α1S subunit (Cav1.1) of voltage-dependent calcium channels, and is required for normal skeletal and cardiac muscle function, where it couples with the ryanodine receptor to regulate muscle contraction. Recently CACNA1S was reported to be expressed on the tips of retinal depolarizing bipolar cells (DBCs) and colocalized with metabotropic glutamate receptor 6 (mGluR6), which is critical to DBC signal transduction. Further, in mGluR6 knockout mice, expression at this location… CONTINUE READING
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