CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity

@article{Ou2015CACNA1CRG,
  title={CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity},
  author={X. Ou and D. Crane and B. MacIntosh and L. Young and B. Goldstein},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2015},
  volume={55},
  pages={198-210}
}
Recently, multiple genome-wide association studies have identified a genetic polymorphism (CACNA1C rs1006737) that appears to confer susceptibility for BD. This article aims to summarize the existing literature regarding the impact of rs1006737 on functional and structural neuroimaging intermediate phenotypes. Twenty eight articles, representing 2486 healthy participants, 369 patients with BD and 104 healthy first-degree relatives of patients with BD, are incorporated. Multiple studies have… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.
  • 28
The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder
  • 65
  • Highly Influential
  • PDF
CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
  • 59
  • Highly Influential
  • PDF
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
  • 449
  • PDF
The association of genetic variation in CACNA1C with structure and function of a frontotemporal system.
  • 73
  • Highly Influential
  • PDF
No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes.
  • 20
  • Highly Influential
The CACNA1C risk variant for bipolar disorder influences limbic activity
  • 83
  • Highly Influential
  • PDF
Effects of a CACNA1C genotype on attention networks in healthy individuals
  • 71
  • Highly Influential
...
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4
5
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