CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance.

@article{Brennan2006CAII,
  title={CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance.},
  author={Donal J Brennan and Karin Jirstrom and Asa Kronblad and Robert C. Millikan and G{\"o}ran Landberg and Michael J. Duffy and Lisa Ryd{\'e}n and William M. Gallagher and Sallyann L O'Brien},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 21},
  pages={6421-31}
}
PURPOSE Hypoxia in breast cancer is associated with poor prognosis and down-regulation of the estrogen receptor. Carbonic anhydrase IX (CA IX) is a hypoxia-inducible gene that has been associated with poor outcome in many epithelial cancers. Previous studies of CA IX in breast cancer have been carried out on mixed cohorts of premenopausal and postmenopausal patients with locally advanced disease and varying treatment regimens. We examined the potential prognostic and predictive role of CA IX in… CONTINUE READING