C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

@inproceedings{Koppers2015C9orf72A,
  title={
C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits},
  author={Max Koppers and Anna Maria Blokhuis and Henk‐Jan Westeneng and Margo L. Terpstra and Caroline A. C. Zundel and Renata Vieira de S{\'a} and Raymond D. Schellevis and Adrian J Waite and Derek J Blake and Jan Herman Veldink and Leonard H van den Berg and R Jeroen Pasterkamp},
  booktitle={Annals of neurology},
  year={2015}
}
OBJECTIVE How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain- and loss-of-function mechanisms have been proposed. Evidence supporting these mechanisms in vivo is, however, incomplete. Here we determined the effect of C9orf72 loss-of-function in mice. METHODS We generated and analyzed a conditional C9orf72 knockout mouse model. C9orf72(fl/fl) mice were crossed with Nestin-Cre mice to selectively remove C9orf72… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 20 times over the past 90 days. VIEW TWEETS
69 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…