C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.

@article{Friedman2004C8orf4IA,
  title={C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.},
  author={Joshua B Friedman and Elaine B Brunschwig and Petra Platzer and Keith S Wilson and Sanford D Markowitz},
  journal={International journal of cancer},
  year={2004},
  volume={111 1},
  pages={72-5}
}
Transforming growth factor (TGF) beta mediates a tumor suppressor pathway in human colon epithelial cells. We were interested in identifying and characterizing novel genes regulated by the TGF beta pathway in the colon. We employed expression microarrays to identify transcripts induced by TGF beta in Vaco 330, a colon adenoma cell line. We then used expression microarrays to determine which of these TGF beta induced transcripts are down-regulated in metastatic colon cancer. Northern analysis… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…