C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.

Abstract

OBJECTIVE To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention. DESIGN Double-blind, placebo-controlled intervention study. Two outpatient fertility clinics and nine midwifery… (More)

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Cite this paper

@article{Ebisch2003C677TMR, title={C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.}, author={Inge M W Ebisch and Waander L van Heerde and Chris M. Thomas and Nathalie M J van der Put and Wai Yee Wong and R{\'e}gine P. M. Steegers-Theunissen}, journal={Fertility and sterility}, year={2003}, volume={80 5}, pages={1190-4} }