C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

@article{Wu2016C66AD,
  title={C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21},
  author={Hao Wu and Lili Kong and Yi Tan and P N Epstein and Jun Zeng and Junlian Gu and Guang Liang and Maiying Kong and Xiangmei Chen and Lining Miao and Lu Cai},
  journal={Diabetologia},
  year={2016},
  volume={59},
  pages={1558-1568}
}
Diabetic nephropathy is the leading cause of end-stage renal disease. Previously we reported that C66, a novel analogue of curcumin with a very high bioavailability, ameliorated diabetic nephropathy in mice, with little known about the mechanism. The present study aimed to define the mechanism by which C66 ameliorates diabetic nephropathy. Our aim was to discover whether C66 acts through the activation of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2), which governs the… CONTINUE READING
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