C6-Like and C3-Like Molecules from the Cephalochordate, Amphioxus, Suggest a Cytolytic Complement System in Invertebrates

@article{Suzuki2002C6LikeAC,
  title={C6-Like and C3-Like Molecules from the Cephalochordate, Amphioxus, Suggest a Cytolytic Complement System in Invertebrates},
  author={Miho Suzuki and Noriyuki Satoh and Masaru Nonaka},
  journal={Journal of Molecular Evolution},
  year={2002},
  volume={54},
  pages={671-679}
}
Abstract. The mammalian immune system has cytotoxic mechanisms, both cellular and humoral, that destroy the membrane integrity of target cells. The main effector molecules of these cytolytic mechanisms—perforin, used by killer lymphocytes, and the membrane attack complex (MAC) components of the complement system—share a unique module called the MAC/perforin module. Until now, both immunological cytotoxicity and the MAC/perforin module have been reported only in jawed vertebrates. Here, we… CONTINUE READING
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