C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha

@article{Okusawa1988C5aSS,
  title={C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha},
  author={Seijiro Okusawa and Kim B. Yancey and Jos W M van der Meer and Stefan Endres and Gerhard Lonnemann and K Hefter and Mike Frank and John F. Burke and Charles A Dinarello and Jeffrey Gelfand},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={168},
  pages={443 - 448}
}
We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-alpha, IL-1 beta, and IL-1 alpha, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-alpha and IL-1 beta secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1 alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of… CONTINUE READING