C5a-induced histamine release. Species specificity.

  title={C5a-induced histamine release. Species specificity.},
  author={Jean F. Regal and T M Hardy and Francis B. Casey and Lawrence William Chakrin},
  journal={International archives of allergy and applied immunology},
  volume={72 4},
C5a has long been known to cause histamine release from isolated perfused guinea pig lung, isolated human basophils, rat and guinea pig mast cells, and guinea pig skin. The purpose of the present study was to compare the ability of guinea pig C5a to cause histamine release from lung fragments of dog, rabbit and rat with that released from guinea pig lung fragments. In addition, C5a-induced histamine release from the skin of the guinea pig, rabbit, and rat was investigated by examining… 

Inability of rat anaphylatoxin to induce histamine release in rats.

It is suggested that rat anaphylatoxin does not participate in histamine release and increased vascular permeability in the zymosan-air-pouch inflammation.

Non-IgE-mediated mast cell stimulation.

  • F. Pearce
  • Biology, Medicine
    Ciba Foundation symposium
  • 1989
Data emphasized the functional heterogeneity of mast cells from different locations and highlight the particular pharmacological properties of the skin mast cell in man, as well as questioning the role of neuronal mast cell activation in allergy and inflammation.

The role of C5a in hypersensitivity reactions in the lung.

  • J. Regal
  • Medicine, Biology
    Pulmonary pharmacology
  • 1989

Human C5a induces a substantial histamine release in human basophils but not in tissue mast cells.

The histamine-releasing effect of human C5a was compared with that of concanavalin A in blood basophils and isolated adenoidal mast cells from the same donors, and the results support the view that the heterogeneity of mast cells and basophile is also reflected in the expression of anaphylatoxin receptors on their surface.

Inhibition of C5a-induced basophil degranulation by disodium cromoglycate

Results indicate that C 5a induces the degranulation of both basophils and mast cells in the guinea pig, and that C5a-induced degranulations of basophil, but not mast cells, is inhibited by DSCG.

Histamine, Histamine Antagonists and Cromones

There was an extensive study of its biological effects by DALE and LAIDLAW (1910,1911), who noted the parallel between the actions of histamine in animals and the response of an animal to a foreign protein, normally inert, but to which the animal had been sensitised by prior injection.

The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man

Of the complement peptides comprising anaphylatoxin activity, only C5a caused a very small (<1.5%) but statistically significant histamine release from isolated human adenoidal mast cells. C3a and

Differential role of neutrophils and monocytes during subcutaneous plasma extravasation

Leukocyte-induced plasma extravasation is specific for PMN, and is not due to a physical leakage of plasma during leukocyte emigration, but is probably caused by a cognate interaction between PMNs and postcapillary venule endothelial cells.