C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.

@article{Okazaki2011C5aCT,
  title={C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.},
  author={Natsumi Okazaki and K. Hazeki and T. Izumi and K. Nigorikawa and O. Hazeki},
  journal={Journal of biochemistry},
  year={2011},
  volume={149 3},
  pages={
          265-74
        }
}
  • Natsumi Okazaki, K. Hazeki, +2 authors O. Hazeki
  • Published 2011
  • Biology, Medicine
  • Journal of biochemistry
  • The complement system is a classic central player in innate immunity. Most pathogens activate both complement and the toll-like receptor (TLR) pathway. Therefore, to provide a more comprehensive understanding of innate immunity, it is important to understand the crosstalk between these two systems. Mouse macrophages produce IL-12 and IL-10 in response to TLR ligands such as LPS, CpG, Poly I:C and Malp2. The TLR-induced IL-12 production was decreased, while that of IL-10 was increased by… CONTINUE READING
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    References

    SHOWING 1-10 OF 31 REFERENCES
    Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • 3,453
    Selective Suppression of IL-12 Production by Chemoattractants
    • 189
    • PDF
    PI3K-mediated negative feedback regulation of IL-12 production in DCs
    • 571
    Role of phosphoinositide 3-kinase in innate immunity.
    • 200
    • PDF