C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome.

@article{Kambas2008C5aAT,
  title={C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome.},
  author={Konstantinos Kambas and Maciej M Markiewski and Ioannis A. Pneumatikos and Stavros S. Rafail and Vassiliki Theodorou and Dimitrios Konstantonis and Ioannis Kourtzelis and Michael Doumas and Paola Magotti and Robert A. DeAngelis and John D. Lambris and Konstantinos Ritis},
  journal={Journal of immunology},
  year={2008},
  volume={180 11},
  pages={
          7368-75
        }
}
Acute respiratory distress syndrome (ARDS) is characterized by the presence of fibrin-rich inflammatory exudates in the intra-alveolar spaces and the extensive migration of neutrophils into alveoli of the lungs. Tissue factor (TF)-dependent procoagulant properties of bronchoalveaolar lavage fluid (BALF) obtained from ARDS patients favor fibrin deposition, and are likely the result of cross-talk between inflammatory mediators and hemostatic mechanisms. However, the regulation of these… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

Systemic inflammation in xenograft recipients precedes activation of coagulation.

  • Xenotransplantation
  • 2015
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Neutrophil extracellular traps (NETs) - formation and implications.

  • Acta biochimica Polonica
  • 2013
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.

  • American journal of respiratory cell and molecular biology
  • 2013
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED