C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

  title={C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a},
  author={N Chen and Christine Mirtsos and Daniel Suh and Yong-Chen Lu and W Lin and Colin McKerlie and Taeweon Lee and Helene Baribault and Hui Tian and W E Yeh},
Complement-derived anaphylatoxins regulate immune and inflammatory responses through G-protein-coupled receptor (GPCR)-mediated signalling. C5L2 (also known as GPR77) is a relatively new GPCR thought to be a non-signalling receptor binding to C5a, on the basis of sequence information and experimental evidence. Here we show, using gene targeting, that C5L2 is required to facilitate C5a signalling in neutrophils, macrophages and fibroblasts in vitro. Deficiency of C5L2 results in reduced… CONTINUE READING
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