• Medicine
  • Published in The Journal of rheumatology 1999

C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus.

@article{Sullivan1999C4ADD,
  title={C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus.},
  author={Kathleen E Sullivan and Natalie A. Kim and Daphne Goldman and Michelle A Petri},
  journal={The Journal of rheumatology},
  year={1999},
  volume={26 10},
  pages={
          2144-7
        }
}
OBJECTIVE The association of C4A deficiency with systemic lupus erythematosus (SLE) is well documented. In Caucasian populations, the most common cause of C4A deficiency is a large gene deletion in linkage disequilibrium with a conserved MHC haplotype. Because of this linkage disequilibrium, it has been difficult to determine which of the genes constitutes the disease susceptibility allele. Evidence from non-caucasoid populations has supported a role for C4A deficiency in SLE. We investigated… CONTINUE READING

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