C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge

Abstract

The ability of the C3d component of complement to enhance antibody responses and protective immunity to influenza virus challenges was evaluated using a DNA vaccine encoding a C3d fusion of the hemagglutinin (HA) from influenza virus. Plasmids were generated that encoded a transmembrane HA (tmHA), a secreted form of HA (sHA), or a sHA fused to three tandem… (More)
DOI: 10.1038/77802

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@article{Ross2000C3dEO, title={C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge}, author={Ted M Ross and Yan Xu and Rick A. Bright and Harriet L Robinson}, journal={Nature Immunology}, year={2000}, volume={1}, pages={127-131} }