C3a-induced contraction of guinea pig ileum consists of two components: fast histamine-mediated and slow prostanoid-mediated.

@article{Balzo1989C3ainducedCO,
  title={C3a-induced contraction of guinea pig ileum consists of two components: fast histamine-mediated and slow prostanoid-mediated.},
  author={U H del Balzo and Margaret J. Polley and Roberto Levi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={248 3},
  pages={1003-9}
}
Guinea pig ileum is the classical experimental model for assessing the biological activity of complement-derived anaphylatoxins. Nevertheless, it is still at issue whether C3a-induced ileal contraction is entirely dependent on histamine release. We report that the contraction of the intestinal smooth muscle in response to C3a is characterized by two… CONTINUE READING