C3H/HeJ mice are refractory to lipopolysaccharide in the brain

@article{Johnson1997C3HHeJMA,
  title={C3H/HeJ mice are refractory to lipopolysaccharide in the brain},
  author={Rodney W Johnson and Gilles Gheusi and S. Segreti and Robert Dantzer and Keith W. Kelley},
  journal={Brain Research},
  year={1997},
  volume={752},
  pages={219-226}
}
C3H/HeJ mice are refractory to lipolysaccharide (LPS) in the periphery, primarily because their macrophages do not respond to LPS and produce pro-inflammatory cytokines such as interleukin-1 (IL-1). To determine if they are also refractory to LPS in the brain, behavior of C3H/HeJ mice was compared to LPS-sensitive C3H/HeOuJ mice following intracerebroventricular (I.C.V.) injection of LPS. Whereas ICV injection of LPS (3-1000 ng/mouse) depressed social behavior, food motivation, object… CONTINUE READING

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