C3H/HeJ mice are refractory to lipopolysaccharide in the brain

  title={C3H/HeJ mice are refractory to lipopolysaccharide in the brain},
  author={Rodney W Johnson and Gilles Gheusi and S. Segreti and Robert Dantzer and Keith W. Kelley},
  journal={Brain Research},
C3H/HeJ mice are refractory to lipolysaccharide (LPS) in the periphery, primarily because their macrophages do not respond to LPS and produce pro-inflammatory cytokines such as interleukin-1 (IL-1). To determine if they are also refractory to LPS in the brain, behavior of C3H/HeJ mice was compared to LPS-sensitive C3H/HeOuJ mice following intracerebroventricular (I.C.V.) injection of LPS. Whereas ICV injection of LPS (3-1000 ng/mouse) depressed social behavior, food motivation, object… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…