C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.

@article{Hur2008C3435TPO,
  title={C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.},
  author={Eun-Hye Hur and Jae-Hong Lee and Michael J. Lee and Seong-jun Choi and Jung Hee Lee and Mun Jung Kang and Miee Seol and Yae Eun Jang and Hee-Jung Lee and Ip-Sol Kang and Soo-Kyung Shim and Seong-Gil Ryu and Y S Kang and Y S Lee and Chan Park and Hyun-sook Chi and K A Lee},
  journal={Leukemia research},
  year={2008},
  volume={32 10},
  pages={1601-4}
}
We investigated the association between the MDR1 C3435T polymorphism and P-glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with AML, excluding the M3 subtype. The CC, CT and TT genotype frequencies of the C3435T polymorphism among patients were 71, 93 and 36, respectively. The C3435T polymorphism genotypes did not have influence on the P-glycoprotein function of leukemic blasts. Complete remission rates and overall, relapse-free and event-free survival… CONTINUE READING

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