C3 glomerulopathy in adults: a distinct patient subset showing frequent association with monoclonal gammopathy and poor renal outcome

Abstract

BACKGROUND C3 glomerulopathy (C3G) includes both C3 glomerulonephritis (C3GN) and dense deposit disease (DDD) and is defined by C3-dominant deposits on immunofluorescence. Dysfunction of the alternative pathway (AP) of complement is central to the pathophysiology of C3G and young patients often harbor genetic alterations of AP mediators. Recently, a link… (More)

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Cite this paper

@inproceedings{Lloyd2016C3GI, title={C3 glomerulopathy in adults: a distinct patient subset showing frequent association with monoclonal gammopathy and poor renal outcome}, author={Isaac E. Lloyd and Alexander J. Gallan and Hunter K. Huston and Kalani L. Raphael and Dylan V. Miller and Monica Patricia Revelo and Mazdak A. Khalighi}, booktitle={Clinical kidney journal}, year={2016} }