C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up.

@article{Sethi2012C3GC,
  title={C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up.},
  author={Sanjeev Sethi and Fernando C Fervenza and Yuzhou Zhang and Ladan Zand and Julie A. Vrana and Samih H. Nasr and Jason D. Theis and Ahmet Dogan and Richard J. H. Smith},
  journal={Kidney international},
  year={2012},
  volume={82 4},
  pages={465-73}
}
C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical features, kidney biopsy findings, AP abnormalities, glomerular proteomic profile, and follow-up in 12 cases of C3GN. This disorder equally affected all ages, both genders, and typically presented with hematuria and proteinuria. In both the short and long term, renal function remained stable in the majority of… CONTINUE READING
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