C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction.

@article{Guescini2010C2C12MR,
  title={C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction.},
  author={Michele Guescini and Diego Guidolin and Luciana Vallorani and Lucia Casadei and Anna Maria Gioacchini and Pasquale Tibollo and Maurizio Battistelli and Elisabetta Falcieri and Leontino Battistin and Luigi Francesco Agnati and Vilberto Stocchi},
  journal={Experimental cell research},
  year={2010},
  volume={316 12},
  pages={1977-84}
}
Micro-vesicles can be released by different cell types and operate as 'safe containers' mediating inter-cellular communication. In this work we investigated whether cultured myoblasts could release exosomes. The reported data demonstrate, for the first time, that C2C12 myoblasts release micro-vesicles as shown by the presence of two exosome markers (Tsg101 and Alix proteins). Using real-time PCR analysis it was shown that these micro-vesicles, like other cell types, carry mtDNA. Proteomic… CONTINUE READING

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