C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

@article{Bai2002C2AAA,
  title={C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.},
  author={Jihong Bai and Ping Wang and Edwin R Chapman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 3},
  pages={1665-70}
}
Synaptotagmin (syt) I, an integral membrane protein localized to secretory vesicles, is a putative Ca(2+) sensor for exocytosis. Its N terminus spans the membrane once, and its cytoplasmic domain contains two conserved C2 domains, designated C2A and C2B. The isolated C2A domain penetrates membranes in response to Ca(2+); isolated C2B does not. Here, we have addressed the function of each C2 domain, but in the context of the intact cytoplasmic domain (C2A-C2B), by using fluorescent reporters… CONTINUE READING

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