C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.

@article{Wyche2004C242TCP,
  title={C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.},
  author={Keith E Wyche and Shaoshan S. Wang and Kathy K. Griendling and Sergey I. Dikalov and Harland Austin and Swapna Tadishetty Hanumanth Rao and Bruno Fink and David G Harrison and Abarmard Maziar Zafari},
  journal={Hypertension},
  year={2004},
  volume={43 6},
  pages={1246-51}
}
Oxidative stress contributes to the pathogenesis of atherosclerosis. p22phox-based NAD(P)H oxidases exist in the vessel wall, acting as important superoxide-generating systems in the vasculature. Some studies have identified reduced atherosclerosis in the presence of the C242T CYBA polymorphism, whereas others have not. Because vascular p22phox is identical to neutrophil p22phox, we studied the association between the C242T, A640G, and -930A/G CYBA polymorphisms and the quantity of superoxide… CONTINUE READING