C21ORF105, A chromosome 21-encoded mRNA, is not a discriminative marker gene for prediction of Down syndrome in maternal plasma.

@article{Go2007C21ORF105AC,
  title={C21ORF105, A chromosome 21-encoded mRNA, is not a discriminative marker gene for prediction of Down syndrome in maternal plasma.},
  author={Attie T. J. I. Go and Allerdien Visser and M. A. Mulders and Jos W. R. Twisk and Marinus A. Blankenstein and John M. G. van Vugt and Cees B. M. Oudejans},
  journal={Prenatal diagnosis},
  year={2007},
  volume={27 2},
  pages={146-9}
}
OBJECTIVES The presence and detectability of placental mRNA in maternal plasma opens possibilities for the development of non-invasive prenatal diagnostic tests. In this study, we tested C21orf105, a chromosome 21-encoded, placentally expressed gene, in maternal plasma of women carrying a fetus with or without trisomy 21. METHODS Using real-time RT-PCR, we determined transcript levels of target (C21orf105) and reference (hPL) genes in first-trimester plasma samples. Plasma was obtained from… CONTINUE READING

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