C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells.

@article{Qian2017C21SG,
  title={C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells.},
  author={Xicheng Qian and Bao-cai Li and Peng Li and Dong Wang and Weifeng Dai and Mi Zhang},
  journal={Phytochemistry},
  year={2017},
  volume={140},
  pages={
          1-15
        }
}
Neuroprotection of two C21 steroidal glycosides from Cynanchum auriculatum against H2O2-induced damage on PC12 cells
TLDR
Experiments showed that compounds 1 and 2 can both regulate the activities of antioxidant enzymes, including GSH-Px, LDH, CAT, SOD, decrease the levels of intracellular ROS and Ca2+, reduce cell apoptosis, and play the role of neuroprotection against oxidative damage.
New Immunomodulating Polyhydroxypregnane Glycosides from the Roots of Cynanchum otophyllum C.K.Schneid.
TLDR
Seven new polyhydroxypregnane glycosides, named cynotophyllosides P–V, together with three known analogs were isolated from the roots of Cynanchum otophyllum C and showed immunomodulatory activities as it enhanced the proliferation of splenocytes in low concentration and suppressed immune cells in concentration more than 1.0 μg/ml.
Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
TLDR
In this review, the morphology characteristics, species identification, and the relationship of botany, extraction and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species are summarized for the first time.
Cytotoxic Polyhydroxylated Oleanane Triterpenoids from Cissampelos pareira var. hirsuta
Three new polyhydroxylated oleanane triterpenoids, cissatriterpenoid A−C (1−3), along with one known analogue (4), were isolated from the whole plant of Cissampelos pareira var. hirsuta. Their
Sesqui- and Diterpenoids from the Radix of Curcuma aromatica.
TLDR
The antioxidant activities of compounds 1-27 were evaluated based on their ability to protect PC12 cells against H2O2-induced damage, with 1, 2, 5-8, 11, 12, 14, 16, 18, and 19 exhibiting notable antioxidant effects on oxidative injury induced by H2 O2.
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References

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Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight.
A polysaccharide isolated from Cynomorium songaricum Rupr. protects PC12 cells against H2O2-induced injury.
C21 steroidal glycosides from the roots of Cynanchum saccatum
Neuroprotective polyhydroxypregnane glycosides from Cynanchum otophyllum
Cytotoxicity of pregnane glycosides of Cynanchum otophyllum
A New Steroidal Glycoside from Roots of Cynanchum auriculatum
Objective To study the chemical constituents of Cynanchum auriculatum.Methods Two steroidal glycosides were purified by column chromatography and their structures were elucidated by spectroscopic
Three New Steroidal Glycosides from the Roots of Cynanchum auriculatum
TLDR
Three new steroidal glycosides, cyanoauriculosides F, G and H, were isolated from the roots of Cynanchum auriculatum along with two known steroidal derivatives.
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