C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.

@article{Nalefski2001C2DF,
  title={C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.},
  author={Eric A. Nalefski and Mark A Wisner and Jun Chen and Stephen R Sprang and Masakazu Fukuda and Katsuhiko Mikoshiba and Joseph J. Falke},
  journal={Biochemistry},
  year={2001},
  volume={40 10},
  pages={3089-100}
}
The ubiquitous C2 domain is a conserved Ca2+ triggered membrane-docking module that targets numerous signaling proteins to membrane surfaces where they regulate diverse processes critical for cell signaling. In this study, we quantitatively compared the equilibrium and kinetic parameters of C2 domains isolated from three functionally distinct signaling proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein kinase C-beta (PKC-beta), and synaptotagmin-IA (Syt-IA). The results show that… CONTINUE READING

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