C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration

@article{Jang2005C2ceramideIV,
  title={C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration},
  author={Gil-Jin Jang and Duck Sun Ahn and Y K Cho and Kathleen G Morgan and Young-Ho Lee},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2005},
  volume={372},
  pages={242-250}
}
It is known that ceramide may play an important regulatory role in vascular tone although its effect on vascular tone and the mechanisms involved are controversial. The present study was designed to investigate the effects of ceramide and its key initial regulators, TNF-α and neutral sphingomyelinase (SMase), on vascular tone of isolated rat thoracic aortic rings and elucidate the mechanisms involved in the changes in vascular tone induced by ceramide. Contractile responses and Fura-2 Ca2… CONTINUE READING

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Highly Influenced

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