C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy.

@article{McGonigal2016C1qtargetedIO,
  title={C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy.},
  author={Rhona McGonigal and Madeleine E. Cunningham and Denggao Yao and Jennifer A. Barrie and Sethu Sankaranarayanan and Simon Ngamli Fewou and Koichi Furukawa and Ted A. Yednock and Hugh John Willison},
  journal={Acta neuropathologica communications},
  year={2016},
  volume={4},
  pages={23}
}
INTRODUCTION Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options. The pathogenesis of the acute motor axonal neuropathy (AMAN) variant is mediated by complement-fixing anti-ganglioside antibodies that directly bind and injure the axon at sites of vulnerability such as nodes of Ranvier and nerve terminals. Consequently, the complement cascade is an… CONTINUE READING