C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation.

@article{Teh2011C1qRO,
  title={C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation.},
  author={Boon King Teh and Joo Guan Yeo and Lai Min Chern and Jinhua Lu},
  journal={Molecular immunology},
  year={2011},
  volume={48 9-10},
  pages={1128-38}
}
The causative association of complement C1q deficiency with systemic lupus erythematosus (SLE), which inevitably involves the breakdown of tolerance, remains poorly explained. Its non-hepatic, macrophage and dendritic cell (DC) origin may be highly relevant. In tissues, C1q is produced by DCs and macrophages which deposits around these cells and we ask whether this pericellular form of C1q regulates DC development from monocytes. DCs cultured on immobilized C1q (C1q-DCs) show similar MHC, CD40… CONTINUE READING

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