C1q knock-out mice for the study of complement deficiency in autoimmune disease.

@article{Botto1998C1qKM,
  title={C1q knock-out mice for the study of complement deficiency in autoimmune disease.},
  author={Marina Botto},
  journal={Experimental and clinical immunogenetics},
  year={1998},
  volume={15 4},
  pages={231-4}
}
  • Marina Botto
  • Published 1998 in Experimental and clinical immunogenetics
In humans, homozygous deficiency of the first component of the classical pathway of complement, C1q, is a powerful disease susceptibility factor for the development of systemic lupus erythematosus (SLE). This strong association indicates that a functional activity of C1q protects from the development of SLE. Studies in vitro have shown that C1q can bind apoptotic keratinocytes suggesting that it may have an important role in the clearance of apoptotic cells. C1q-deficient mice, generated by… CONTINUE READING

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