C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.

@article{Baruah2009C1qEI,
  title={C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.},
  author={Paramita Baruah and Ingrid Elena Dumitriu and Talat Habib Malik and H Terence Cook and Julian P. Dyson and Diane Scott and E Hatheway Simpson and Marina Botto},
  journal={Blood},
  year={2009},
  volume={113 15},
  pages={3485-93}
}
Dendritic cells (DCs) are known to produce C1q, the initiator of the classical complement pathway. We demonstrate that murine DCs deficient in C1q (C1qa(-/-)) are poorer than wild-type (WT) DCs at eliciting the proliferation and Th1 differentiation of antigen-specific T cells. These defects result from decreased production of IL-12p70 by C1qa(-/-) DCs and impaired expression of costimulatory molecules CD80 and CD86 in response to CD40 ligation. The defective production of IL-12p70 and the… CONTINUE READING

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