C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.

@article{Fraser2006C1qAM,
  title={C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.},
  author={Deborah A Fraser and Suzanne Slater Bohlson and Nijole Jasinskiene and Niraj B. Rawal and Gail M Palmarini and S Magda Teresa Ruiz and Rosemary Rochford and Andrea Joan Tenner},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 1},
  pages={
          107-16
        }
}
It has recently been recognized that the innate immune response, the powerful first response to infection, has significant influence in determining the nature of the subsequent adaptive immune response. C1q, mannose-binding lectin (MBL), and other members of the defense collagen family of proteins are pattern recognition molecules, able to enhance the phagocytosis of pathogens, cellular debris, and apoptotic cells in vitro and in vivo. Humans deficient in C1q inevitably develop a lupus-like… CONTINUE READING
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