C1q: A fresh look upon an old molecule.

  title={C1q: A fresh look upon an old molecule.},
  author={Nicole M Thielens and Francesco Saverio Tedesco and Suzanne Slater Bohlson and Christine Gaboriaud and Andrea Joan Tenner},
  journal={Molecular immunology},
Originally discovered as part of C1, the initiation component of the classical complement pathway, it is now appreciated that C1q regulates a variety of cellular processes independent of complement activation. C1q is a complex glycoprotein assembled from 18 polypeptide chains, with a C-terminal globular head region that mediates recognition of diverse molecular structures, and an N-terminal collagen-like tail that mediates immune effector mechanisms. C1q mediates a variety of immunoregulatory… CONTINUE READING
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