C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts.

@article{Hofmann2011C1qTNFrelatedP,
  title={C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts.},
  author={C Gonzalez Hofmann and Ning Chen and Florian Obermeier and Gisela Paul and Christa Buechler and Andrea Kopp and Werner Falk and Andreas Schaeffler},
  journal={Inflammatory bowel diseases},
  year={2011},
  volume={17 12},
  pages={
          2462-71
        }
}
BACKGROUND The adipokine CTRP-3 (C1q/TNF-related protein-3) belongs to the C1q/TNF-related protein family which antagonizes the effects of lipopolysaccharide (LPS). The aim was to investigate the antiinflammatory and antifibrotic role of CTRP-3 in Crohn's disease (CD). METHODS Mesenteric adipose tissue (MAT) of patients with CD or colonic cancer (CC) was resected. Human primary colonic lamina propria fibroblasts (CLPF) were isolated from controls and CD patients. Concentrations of chemokines… CONTINUE READING
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