C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress.

@article{Bazhenova2017C1473GPI,
  title={C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress.},
  author={Ekaterina Yu Bazhenova and Daria V Bazovkina and Elizabeth A. Kulikova and Dariya V Fursenko and Nikita V Khotskin and Daria V. Lichman and Alexander Kulikov},
  journal={Neuroscience letters},
  year={2017},
  volume={640},
  pages={
          105-110
        }
}
Neurotransmitter serotonin (5-HT) is involved in the regulation of stress response. Tryptophan hydroxylase-2 (TPH2) is the key enzyme of serotonin (5-HT) synthesis in the brain. C1473G polymorphism in Tph2 gene is the main factor defining the enzyme activity in the brain of laboratory mice. The effect of interaction between C1473G polymorphism and 30min restriction stress on the behavior in the open field test, c-Fos gene expression and 5-HT metabolism in the brain in adult male of B6-1473C and… CONTINUE READING