C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.

@article{Desmurs2015C11orf83AM,
  title={C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.},
  author={Marjorie Desmurs and Michelangelo Foti and Etienne Raemy and Fr{\'e}d{\'e}ric M Vaz and J C Martinou and Amos Bairoch and Lydie Lane},
  journal={Molecular and cellular biology},
  year={2015},
  volume={35 7},
  pages={1139-56}
}
Mammalian mitochondria may contain up to 1,500 different proteins, and many of them have neither been confidently identified nor characterized. In this study, we demonstrated that C11orf83, which was lacking experimental characterization, is a mitochondrial inner membrane protein facing the intermembrane space. This protein is specifically associated with the bc1 complex of the electron transport chain and involved in the early stages of its assembly by stabilizing the bc1 core complex… CONTINUE READING
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