C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats.

@article{Abbott2012C1NE,
  title={C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats.},
  author={Stephen B G Abbott and Roy Kanbar and Genrieta Bochorishvili and Melissa B. Coates and Ruth L Stornetta and Patrice G Guyenet},
  journal={The Journal of physiology},
  year={2012},
  volume={590 12},
  pages={2897-915}
}
C1 neurons activate sympathetic tone and stimulate the hypothalamic–pituitary–adrenal axis in circumstances such as pain, hypoxia or hypotension. They also innervate pontine noradrenergic cell groups, including the locus coeruleus (LC) and A5. Activation of C1 neurons reportedly inhibits LC neurons; however, because these neurons are glutamatergic and have excitatory effects elsewhere, we re-examined the effect of C1 activation on pontine noradrenergic neurons (LC and A5) using a more selective… CONTINUE READING
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