C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide.

@article{Liu2003C1IP,
  title={C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide.},
  author={Dongxu Liu and Shenghe Cai and Xiaogang Gu and Jennifer Scafidi and X. D. Wu and Alvin E. Davis},
  journal={Journal of immunology},
  year={2003},
  volume={171 5},
  pages={
          2594-601
        }
}
C1 inhibitor (C1INH) is beneficial in animal models of endotoxemia and sepsis. However, the mechanism(s) of C1INH protection remain(s) ill-defined. In this study, we demonstrated that both active C1INH and reactive center-cleaved, inactive C1INH protected mice from lethal Gram-negative endotoxemia. Both forms of C1INH blocked the LPS-binding protein-dependent binding of Salmonella typhimurium LPS to the murine macrophage cell line, RAW 264.7, and suppressed LPS-induced TNF-alpha mRNA expression… CONTINUE READING
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