C. elegans tubby regulates life span and fat storage by two independent mechanisms.

@article{Mukhopadhyay2005CET,
  title={C. elegans tubby regulates life span and fat storage by two independent mechanisms.},
  author={A. Mukhopadhyay and B. Deplancke and A. J. Walhout and H. Tissenbaum},
  journal={Cell metabolism},
  year={2005},
  volume={2 1},
  pages={
          35-42
        }
}
In C. elegans, similar to in mammals, mutations in the tubby homolog, tub-1, promote increased fat deposition. Here, we show that mutation in tub-1 also leads to life span extension dependent on daf-16/FOXO. Interestingly, function of tub-1 in fat storage is independent of daf-16. A yeast two-hybrid screen identified a novel TUB-1 interaction partner (RBG-3); a RabGTPase-activating protein. Both TUB-1 and RBG-3 localize to overlapping neurons. Importantly, RNAi of rbg-3 decreases fat deposition… Expand
An endocytic pathway as a target of tubby for regulation of fat storage
TLDR
It is proposed that TUB‐1 controls receptor or sensory molecule degradation in neurons by regulating a RAB‐7‐mediated endocytic pathway. Expand
Nucleolar GTPase NOG-1 Regulates Development, Fat Storage, and Longevity through Insulin/IGF Signaling in C. elegans
TLDR
It is shown that the nog1 ortholog (T07A9.9: nog-1) in C. elegans regulates growth, development, lifespan, and fat metabolism and may be an important player in regulating life span and fat storage via the insulin/IGF pathway. Expand
C. elegans VANG-1 Modulates Life Span via Insulin/IGF-1-Like Signaling
TLDR
A novel role of VANG-1, the only C. elegans ortholog of the conserved PCP component Strabismus/Van Gogh is described and it is shown that two alleles of vang-1 and depletion of the protein by RNAi cause an increase of mean life span up to 40%. Expand
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans
TLDR
It is found that, unlike the intraflagellar transport (IFT) genes, disruption of ifta-2 does not result in overt cilia assembly abnormalities, nor did it cause chemotaxis or osmotic avoidance defects typical of cilia mutants, and it is concluded that IFTA-2 is not a ciliogenic protein but rather a regulator of specific cilia signaling activities. Expand
The C. elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
TLDR
The results describe new functions for Tubby proteins in the dynamic regulation of cilia membrane lipid composition, morphology, and signaling protein content, and suggest that this conserved family of proteins plays a critical role in mediating cilia structural and functional plasticity. Expand
A conserved acetylation switch enables pharmacological control of tubby-like protein stability
TLDR
A signaling pathway that links nuclear enzymes to ciliary membrane receptors via TULP3 is unveiled, a dynamic mechanism for the regulation of all tubby-like proteins is described, and how to exploit it pharmacologically using drugs is explored. Expand
The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
TLDR
The results describe new functions for Tubby proteins in the dynamic regulation of cilia membrane lipid composition, morphology, and signaling protein content, and suggest that this conserved family of proteins plays a critical role in mediating cilia structural and functional plasticity. Expand
Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila.
TLDR
Data suggest TUSP is a novel regulator of SNARE assembly and, therefore, of neurotransmitter release in the Drosophila nervous system, where it is expressed in all neurons. Expand
Mechanisms of aging and development in the nematode caenorhabditis elegans
TLDR
The data reported in this thesis support the view that there is no direct link between the amount of lipid deposits in an organism and a lifespan, and the use of vital lipophilic dye Nile Red for visualizing fat storage droplets in C. elegans is not suitable for monitoring body fat. Expand
Krüppel-like family of transcription factors: an emerging new frontier in fat biology
TLDR
An overview of the most current information on the key regulatory components in fat biology is provided, synthesize the diverse literature, pose new questions, and propose a new model organism for understanding fat biology using KLFs as the central theme. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 56 REFERENCES
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
TLDR
It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway. Expand
Microtubule-associated protein 1A is a modifier of tubby hearing (moth1)
TLDR
The positional cloning of an auditory quantitative trait locus (QTL) is reported, the modifier of tubby hearing 1 gene (moth1), whose wildtype alleles from strains AKR/J, CAST/Ei and 129P2/OlaHsd protect tubby mice from hearing loss. Expand
Signals from the reproductive system regulate the lifespan of C. elegans
TLDR
The C. elegans insulin/IGF-1 system integrates multiple signals to define the animal's rate of ageing, and this study demonstrates an inherent relationship between the reproductive state of this animal and its lifespan, and may have implications for the co-evolution of reproductive capability and longevity. Expand
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homologExpand
The tubby-like proteins, a family with roles in neuronal development and function.
The identification of a mutation at the tubby (Tub) locus, which causes obesity and neurosensory degeneration, led to the discovery of the tubby-like proteins (TULPs). Tub and the genes that encodeExpand
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
TLDR
This work demonstrates that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both lifespan regulation and stress resistance and defines an interaction between two well conserved proteins, JNK-1 and D AF-16, and provides a mechanism by which JNK regulates longevity and stress Resistance. Expand
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
TLDR
Genetic analysis of 17 orthologous genes from Caenorhabditis and Drosophila showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development. Expand
Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span
TLDR
The findings imply that the life span of C. elegans is determined by a signaling cascade in which the DAF-2 receptor acts in multiple cell lineages to regulate the production or activity of a secondary signal (or signals), which, in turn, controls the growth and longevity of individual tissues in the animal. Expand
Molecular Analyses of the Arabidopsis TUBBY-Like Protein Gene Family1
TLDR
Results suggest that AtTLP9 may participate in the ABA signaling pathway, and suggest that TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. Expand
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
TLDR
Analysis of the fat-reducing gene inactivations in insulin, serotonin and tubby signalling mutants of C. elegans, which have increased body fat, identifies a core set of fat regulatory genes as well as pathway-specific fat regulators. Expand
...
1
2
3
4
5
...