C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1

@article{Wang2007CEM,
  title={C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1},
  author={Xiaochen Wang and Jin Wang and Keiko Gengyo-Ando and Lichuan Gu and Chun-ling Sun and Chonglin Yang and Yong Shi and Tetsuo Kobayashi and Yigong Shi and Shohei Mitani and Xiao-song Xie and Ding Xue},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={541-549}
}
Externalization of phosphatidylserine, which is normally restricted to the inner leaflet of plasma membrane, is a hallmark of mammalian apoptosis. It is not known what activates and mediates the phosphatidylserine externalization process in apoptotic cells. Here, we report the development of an annexin V-based phosphatidylserine labelling method and show that a majority of apoptotic germ cells in Caenorhabditis elegans have surface-exposed phosphatidylserine, indicating that phosphatidylserine… CONTINUE READING
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The genetics of Caenorhabditis elegans

  • S. Brenner
  • Genetics
  • 1974

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