C. elegans metallothioneins: response to and defence against ROS toxicity.

@article{ZeitounGhandour2011CEM,
  title={C. elegans metallothioneins: response to and defence against ROS toxicity.},
  author={Sukaina Zeitoun-Ghandour and Oksana Iryna Leszczyszyn and Claudia A Blindauer and Florian M. Geier and Jacob G Bundy and Stephen R. St{\"u}rzenbaum},
  journal={Molecular bioSystems},
  year={2011},
  volume={7 8},
  pages={2397-406}
}
The genome of the nematode Caenorhabditis elegans encodes for two multifunctional metal binding metallothioneins (MTs), CeMT-1 and CeMT-2. Here we applied qPCR to identify a transcriptional up-regulation following the exposure to free radical generators (ROS) paraquat or hydrogen peroxide, a trend that was confirmed with Pmtl::GFP expressing alleles. The deletion of the MT loci resulted in an elevation of in vivo levels of hydrogen peroxide and exposure to ROS caused a reduction in total egg… CONTINUE READING