C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

  title={C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance},
  author={Rachel Kaletsky and Rebecca S. Moore and Geoffrey D. Vrla and Lance R. Parsons and Zemer Gitai and Coleen T. Murphy},
  pages={445 - 451}
Summary: C. elegans must distinguish pathogenic from nutritious bacterial food sources among the many bacteria it is exposed to in its environment1. Here we show that a single exposure to purified small RNAs isolated from pathogenic Pseudomonas aeruginosa (PA14) is sufficient to induce pathogen avoidance, both in the treated animals and in four subsequent generations of progeny. The RNA interference and piRNA pathways, the germline, and the ASI neuron are required for bacterial small RNA… 

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