C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.

  title={C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.},
  author={Heather A Hundley and Ammie A Krauchuk and Brenda L Bass},
  volume={14 10},
Adenosine deaminases that act on RNA (ADARs) are editing enzymes that convert adenosine to inosine in double-stranded RNA (dsRNA). ADARs sometimes target codons so that a single mRNA yields multiple protein isoforms. However, ADARs most often target noncoding regions of mRNAs, such as untranslated regions (UTRs). To understand the function of extensive double-stranded 3' UTR structures, and the inosines within them, we monitored the fate of reporter and endogenous mRNAs that include structured… CONTINUE READING


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