C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.

@article{Hundley2008CEA,
  title={C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.},
  author={Heather A Hundley and Ammie A Krauchuk and Brenda L Bass},
  journal={RNA},
  year={2008},
  volume={14 10},
  pages={2050-60}
}
Adenosine deaminases that act on RNA (ADARs) are editing enzymes that convert adenosine to inosine in double-stranded RNA (dsRNA). ADARs sometimes target codons so that a single mRNA yields multiple protein isoforms. However, ADARs most often target noncoding regions of mRNAs, such as untranslated regions (UTRs). To understand the function of extensive double-stranded 3' UTR structures, and the inosines within them, we monitored the fate of reporter and endogenous mRNAs that include structured… CONTINUE READING

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References

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Showing 1-10 of 43 references

RNA hairpins

  • D. P. Morse, P. J. Aruscavage, B. L. Bass
  • Natl. Acad. Sci
  • 2002
Highly Influential
6 Excerpts

The fate of dsRNA in the nucleus : A p 54 nrbcontaining complex mediates the nuclear retention of promiscuously AtoI edited RNAs

  • G. G. Carmichael
  • Cell
  • 2001
Highly Influential
7 Excerpts

RNA by inosine-specific cleavage. Biochemistry

  • D. P. Morse, B. L. Bass
  • 1999
Highly Influential
5 Excerpts

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