C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins

@article{Raices2008CET,
  title={C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins},
  author={Marcela Raices and Ramiro E Verdun and Sarah A. Compton and Candy I. Haggblom and Jack D. Griffith and Andrew G Dillin and Jan Karlseder},
  journal={Cell},
  year={2008},
  volume={132},
  pages={745-757}
}
Single-strand extensions of the G strand of telomeres are known to be critical for chromosome-end protection and length regulation. Here, we report that in C. elegans, chromosome termini possess 3' G-strand overhangs as well as 5' C-strand overhangs. C tails are as abundant as G tails and are generated by a well-regulated process. These two classes of overhangs are bound by two single-stranded DNA binding proteins, CeOB1 and CeOB2, which exhibit specificity for G-rich or C-rich telomeric DNA… CONTINUE READING