C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.

  title={C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.},
  author={Hyun-Ok Song and Wonhae Lee and Kiyoung An and Hye-suk Lee and Jeong Hoon Cho and Zee-Yong Park and J. Ahnn},
  journal={Journal of molecular biology},
  volume={390 4},
Environmental and physiological stresses such as heat shock, oxidative stress, heavy metals, and pathogenic conditions induce cellular stress response. This response is often mediated by heat shock proteins that function as molecular chaperones. A stress-inducible cochaperone, Sti1/Hop (Hsp organizer protein), functions as an adaptor protein that simultaneously binds with Hsp70 and Hsp90 to transfer client proteins from Hsp70 to Hsp90. However, the biological role of STI-1 in vivo is poorly… CONTINUE READING


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