C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.

@article{Wang2006CES,
  title={C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.},
  author={Y Claire Wang and David E. Levy},
  journal={Current biology : CB},
  year={2006},
  volume={16 1},
  pages={89-94}
}
The DAF-7/TGF-beta pathway in C. elegans interprets environmental signals relayed through amphid neurons and actively inhibits dauer formation during reproductive developmental growth . In metazoans, the STAT pathway interprets external stimuli through regulated tyrosine phosphorylation, nuclear translocation, and gene expression , but its importance for developmental commitment, particularly in conjunction with TGF-beta, remains largely unknown. Here, we report that the nematode STAT ortholog… CONTINUE READING