C. elegans STAT: evolution of a regulatory switch.

  title={C. elegans STAT: evolution of a regulatory switch.},
  author={Y Claire Wang and David E. Levy},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 10},
STAT transcription factors have been implicated in many biological processes, particularly host immune defense and development. Here we characterize a STAT orthologue from the nematode, C. elegans. We show that this protein, termed STA-1, is structurally and functionally related to other vertebrate and invertebrate STAT proteins, recognizing a cis DNA element conserved through phylogeny. Unexpectedly, STA-1 lacks the conserved amino-terminal oligomerization domain found in vertebrate and other… CONTINUE READING
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